To make the sauce, combine the strawberries, sugar, orange zest, and orange juice in a saucepan and bring to a boil. Reduce the heat and simmer until the strawberries are soft and the syrup is slightly thickened, 10–12 minutes. Allow the mixture to cool.
To make the French toast, whisk together the cream cheese, strawberry jam, and vanilla until smooth. Spread the cream cheese mixture on the 10 bread slices. Top 5 of the bread slices with 1/4 cup each of the sliced strawberries, then put the remaining bread slices on top like sandwiches.
Whisk together the eggs, milk, orange juice, and sugar in a shallow bowl. Melt the butter in a skillet over medium heat. Dip the sandwiches into the egg mixture and allow to soak for a few seconds on each side. Cook the sandwiches until light golden brown, 3–4 minutes per side. Transfer to serving plates and drizzle the sauce on top. Serve warm.
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