Perricone MD Power of Neuropeptides Face & Neck Duo

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If Sold Separately: $553.32

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Known as "liquid gold," Perricone MD's best-selling Neuropeptide Facial Cream helps address the appearance of the visible signs of aging. A rich, velvety, fast-absorbing cream makes this the ultimate everyday luxury.

In a study, when cutometer testing was used:
  • 91% showed improvement in skin elasticity immediately after use
  • 91% showed improvement in skin elasticity after four weeks
  • 94% showed improvement in skin firmness, tightness, and tone after four weeks

Neuropeptide Restorative Neck & Chest Therapy is a lightweight cream with broad spectrum SPF 25. And with this special offer, you'll be getting it in a super size!

In a study, after eight weeks:
  • When image analysis was used, 74% saw improvement in the appearance of skin texture on the neck and decollete
  • When Chroma Meter testing was used, 93.5% saw a reduction in the appearance of redness on the decollete
  • When cutometer testing was used, 80.64% saw improvement in skin firmness, tightness, and tone on the neck under the chin
  • When expert grading was used, 77.8% saw improvement in the appearance of photo damage on the decollete

How do I use it: In the morning, apply the Neuropeptide Facial Cream onto areas of a cleansed face, focusing on the contours of the cheeks, forehead, and jawline. Then, apply the Neuropeptide Restorative Neck & Chest Therapy liberally to neck and chest. Begin by massaging along the entire upper chest area in gentle circular motions, moving up the front and back of the neck.

You may notice that the Neuropeptide Facial Cream has a very slight scent, but it should dissipate after application.

From Perricone MD.


  • 4-fl oz Neuropeptide Restorative Neck & Chest Therapy
  • 2.5-fl oz Neuropeptide Facial Cream

Delivery Date Estimate

Reviews & Community QA

Perricone MD Power of Neuropeptides Face & Neck Duo is rated 2.8 out of 5 by 109.
Rated 3 out of 5 by from Great Neck Cream, not so great face cream I absolutely love the neck and chest cream. The tree trunk horizontal lines on my neck have greatly diminished and my chest is not as blotchy and/or red as it used to be. Feels good going on, dries quickly with no stickiness afterwards. In regard to the face cream, I have seen no improvement whatsoever. I have faithfully used it for about 2 months and it feels like a wasted step in my skin care routine. So disappointing. 5 stars for neck cream, 0 stars for face cream = 3 star total.
Date published: 2018-08-12
Rated 2 out of 5 by from Frustrated I loved the "stinky" face neuropeptide. I absolutely hate the new one. Too thick and I don't see the difference in my skin like I did with the "stinky" stuff. I canceled my auto ship on this. If they bring back the original face neuropeptide, I'm back in. It may have smelled bad, but it made such a difference in the look and feel of my skin. This stuff lays on top of the skin and whatever I gained with the original I've lost with this new formula. So frustrated. The neck crème is very good.
Date published: 2018-08-05
Rated 5 out of 5 by from Excellent Product I am a Perricone girl now for sure. This is the first time I tried these two products. No disappointment. My pores become small, my skin texture is like silk. I am in the sun, so my neck is at risk, since I wear hats and my face is protected. After the third application of the neck product, a difference in texture, being smoother was apparent. To me, you can't go wrong with Dr. Perricone. He is the father of peptides and his knowledge of skin care supersedes the rest in the industry. II have ithem on auto-delivery.
Date published: 2018-07-21
Rated 3 out of 5 by from Half & Half I really like the neck cream. It applies easily and I think my neck looks better. I did not see any improvement from the face cream. I wish i could just purchase the neck cream at half the cost of the duo instead of buying the duo
Date published: 2018-07-14
Rated 2 out of 5 by from No improvement for me I purchased this product hoping to see that lifting/firming action to the face they showed and promised during the presentation, BUT after using every single morning for weeks, I do not see any results. I thought this was too good to be true, but I wanted to try it since I really like Dana Bledsoe. This neck SPF in the kit applies nicely on the neck, but I already have a more potent SPF with a higher number for my fair skin which is Josie Maran SPF 47. The neuropeptide facial cream is not worth the cost when it does not deliver.
Date published: 2018-06-30
Rated 1 out of 5 by from Dissapointed A waste of my money, this new formula is not good no longer liquid gold and the neck and cream is unnessary! Change back to the orginal formula, scent and all 'it worked'!!! I think the people that didnt like the scent should have changed product NOT people like me that didnt whine and got really beautiful skin!!!!
Date published: 2018-06-24
Rated 2 out of 5 by from Fishy Smell Pros of this product: Then neck cream with spf has a lovely texture. Not sure if product works. Cons of this product: The firming neck cream has a disgusting fish smell. I thought that Perricone had reformulated these products, because of the smell. Once again disappointed. This has a big price tag, buyer beware. I do expect better from QVC. Will never purchase again. Very Sad.
Date published: 2018-06-20
Rated 1 out of 5 by from Stinky Produc I received this item and used it a few times, stopped using it due to the stinky fish odor it has or rather to me it smells like dead fish, broke me out in hives so I discontinued the use of it
Date published: 2018-06-18
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