Perricone MD Neuropeptide Night Cream

Perricone MD Neuropeptide Night Cream
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What is it: Neuropeptide Night Cream helps address the appearance of wrinkles, helps hydrate skin, softens skin's texture, and helps reduce the look of dry lines.

Who is it for: Anyone looking to help address the appearance of dry lines and wrinkles and help hydrate skin.

Why is it different: Dr. Perricone wanted to create what he refers to as one of his "ultimate tools" for addressing the appearance of wrinkles. He formulated it by using Neuro Oligopeptide Complex, which is formulated with six different neuropeptides. He combined this with other keynote technologies.

In a consumer study, after four weeks of use, 83% reported an improvement in the appearance of fine lines and 83% saw improvement in the appearance of overall lines and wrinkles.

How do I use it: Neuropeptide Night Cream should always be your last product before you apply a moisturizer. You only need a dime-size amount, because it's heavily concentrated. Massage it into the skin to activate it. Apply it up under the chin and jawline. Continue to massage it up behind the ears and around the eye area.

From Perricone MD.


  • 1-fl oz Neuropeptide Night Cream

Delivery Date Estimate

Reviews & Community QA

Perricone MD Neuropeptide Night Cream is rated 3.8 out of 5 by 9.
Rated 5 out of 5 by from Secret Healing This cream is magic. It is like a secret healer..... for the face. Please supersize it! Thank you
Date published: 2018-08-13
Rated 5 out of 5 by from WOW--WHAT A DIFFERENCE--BEST EVER I got in a small size jar of this night cream in a kit around last Christmas and totally forgot about it. Then, I had 4 months of on and off bouts of pneumonia. My skin felt like an orange peal because I was too sick to use my fav Q products every day. I finally remembered about this Perricone night cream a week ago and used purity made simple cleanser followed with the night cream. After 4 nights, my skin looked a decade younger. The dead skin rolled off my face leaving baby soft skin. This is is now my favorite product but the $$$$ scares me. I'm in my mid 60's with DRY skin
Date published: 2017-05-19
Rated 3 out of 5 by from mine came used As others have noted, this was in a kit offered during the holidays I waited to open this for several weeks after I had gave a few of my samples away...This was used, over half gone and finger marks in it. I called Customer Service and was told a replacement kit would be coming, but it never came. I wanted to use this, why I bought the box, as I did with most of the other kits. I am sad I did not get to try as I usually purchase items I like. Will never know about this one. Sad the lady did not tell me the truth at QVC, would have gathered the package back and returned! This is what happens if you waited to order some of the kits after the holidays, used returns re-sold at full price.
Date published: 2017-04-23
Rated 5 out of 5 by from Holy Grail I received this in a box of favorites. It is the most amazing thing I have ever used on my face. I cant believe how beautiful my skin is with this! After using maybe 3 weeks, my daughter told me my skin glowed today. It is amazing
Date published: 2017-04-11
Rated 2 out of 5 by from Jar Was Not Even Half Full!! This product was soo disappointing!!! Not only was it really pricey for the quantity. But the jar was hardly full!!! I bought it for myself as a Xmas gift.but here I am already out if it.been out of it since January.and I got it in December! Just awful! I have been sick .so I haven't had time to call customer service .
Date published: 2017-02-18
Rated 3 out of 5 by from jar not full Ordered the TSV and this was one of the products. Jar was only a little over half full. Same thing with the Daily Moisturizer. Did not send back as this is the only product that works for my sensitive skin. I hope future shipments do not reflect this last one.Love the product but please fix the quantity issue.
Date published: 2017-02-03
Rated 5 out of 5 by from Great Scent, Silky Feel I received a sample in one of the QVC beauty boxes that incidentally was only have the cost of this single product and included some other products I use routinely. Although I already have a pretty thorough skin regimen, I opted to add this in. For starters, this cream is very concentrated and a very small amount really does go a long way! (You've never heard that before, right?) This time it's actually true. The scent is subtle, extremely soothing, and spa-like, and almost worth applying on its merit alone. But the way it feels on your skin is amazing...very silky, rich, and not at all greasy. My skin instantly drank it in, especially around my eyes. Even better was the way it made my skin look and feel! The delicate area around my eyes was visibly more hydrated and plump even after my first use. I haven't used it long enough to speak to its long-term efficacy, but I will definitely be continuing to include this nightly. I am a pretty dedicated Isomers user, but plan to do more research on Perricone products thanks to this lovely cream.
Date published: 2017-01-01
Rated 1 out of 5 by from Disappointed I purchased the packaged trio that included Neuropeptide Night Cream, Cold Plasma Sub D, and Face Finishing Moisturizer. The Neuropeptide Night Cream gave my skin wide red streaks across my face and neck with burning where the streaks appeared. Very unpleasant!! No side effects from the Cold Plasma Sub D (which I've used in the past with no significant improvement, but I'll give it another chance). No side effects from the Face Finishing Moisturizer (which smells like rose water) and no real improvement in my skin.
Date published: 2016-10-03
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