Perricone MD Neuropeptide Night Cream 2.5 oz. Auto-Delivery

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or 5 Easy Pays of $48.00

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The One You've Been Seeking

"Dr. Perricone has done it again! He's created a product, years in the making, that no other Perricone product has ever been able to do... Dr. Perricone is using six new neuropeptides he hasn't used in any other product. This is the answer you've been waiting for to address those wrinkles."

—Dana Bledsoe

What is it: Neuropeptide Night Cream helps address the appearance of wrinkles, helps hydrate skin, softens skin's texture, and helps reduce the look of dry lines. And thanks to this handy Auto-Delivery plan, you'll receive a new shipment approximately every six months for two years.

Who is it for: Anyone looking to help address the appearance of dry lines and wrinkles and help hydrate skin.

Why is it different: Dr. Perricone wanted to create what he refers to as the "ultimate tool" for addressing the appearance of wrinkles. He formulated it by using Neuro Oligopeptide Complex, which is formulated with six different neuropeptides. He combined this with other keynote technologies, along with his unique delivery system.

After four weeks of use in a consumer study, 83% reported an improvement in the appearance of fine lines and 83% saw improvement in the appearance of overall lines and wrinkles.

How do I use it: Neuropeptide Night Cream should always be your last product before you apply a moisturizer. You only need a dime-sized amount, because it's heavily concentrated. Massage it into the skin to activate it. Apply it up under the chin and jawline. Continue to massage it up behind the ears and around the eye area.

From Perricone MD.

  • Each shipment includes 2.5-fl oz Neuropeptide Night Cream; shipments arrive approximately every six months for two years
  • Please click on the About Auto-Delivery tab for more information

Important Details

If you take advantage of both Auto-Delivery and Easy Pay™, it is possible that more than one Easy Pay installment could be due in the same month. For example, if your Auto-Delivery plan ships every three months and you select 4 Easy Pay installments, you would pay the fourth installment of your first shipment in the same month you pay the first installment of your second shipment.

Delivery Date Estimate

Reviews & Community QA

Perricone MD Neuropeptide Night Cream 2.5 oz. Auto-Delivery is rated 3.6 out of 5 by 89.
Rated 5 out of 5 by from Flawless skin This has dramatically changed my skin. I am 45 and have very dry skin. I have been using this for over a year along with the serum and daily moisture which a receive in a kit on auto delivery . This has made my skin flawless. No more dry patches, large pores, or red splotches. Only glowing skin. I can’t tell you how many times I’ve been stopped and asked what do you use on your skin it’s just flawless. Perricone of course. Worth the money. Your skin deserves it !
Date published: 2018-10-10
Rated 2 out of 5 by from Very Disappointed I have been using this product for a while. I have to agree with other postings, it has a very greasy feel and does not absorb. Another problem is that the product separates in the tube. I try shaking it well before I open it each night, but the oil still comes out first. Sadly, it is too late to return.
Date published: 2017-10-10
Rated 3 out of 5 by from Greasy, but works I have the day version of this and I love it. I wanted to have the full effect and got this as well. This one doesn't have the smell the day one has (which makes me wonder if it is as potent...) and I find it greasy. Cannot put it on before going to bed, pillow case looks like a mess come morning! So I started using it in the morning, I have a long commute to work and most of it is absorbed by the time I reach my destination. It's not it's recommended use, but at least I'm not wasting it.
Date published: 2017-05-22
Rated 1 out of 5 by from Smells awful and does nothing I got this in a tsv which I will be paying for until August, because I wanted to try his brand. This 'new' formulation seperated as it comes out of the tube, and stinks like fish. I just called to cancel auto- delivery of the 3 products that came, at a 'bargain' price of 'only' way too much split into 6 payments of (edited out the specifics, here), I thought I had successfully canceled it already, but there'd been a miscommunication. I have never been this disappointed by any brand or product, ever. I wish the good Dr. had given us more than 30 days to suffer through the stench of this stuff, because now I am stuck with it, and using it on areas far, far away from my nose. My cats, hilariously, LOVE this stuff. I woke up not long after I had rcvd it to find 2 out of 3 of them going to town on it, where I had put it on my feet. It tickled. I am very lucky not to have had a horrible allergic reaction to it, and am sticking with Dr. Denese, and Paula's Choice, which are much more affordable, esp. if you are diligent, and don't wind up with more frequent shipments than you need. I am happy for those of you for whom this did work, but I am not one of them.
Date published: 2017-05-16
Rated 5 out of 5 by from Firmer Skin I have been using this for 4 months, night and day, and my skin looks more smooth, firm and younger. I decided to write a review cause yesterday someone told me I looked "glamorous "!! Woohoo!! A few months ago I felt my skin needed something else. I do not have wrinkles but my face started looking... not sure how to say, but I thought I would try this. Got it n a TSV, and love It! Another Huge plus is that it does not smell like the day cream.
Date published: 2017-04-27
Rated 4 out of 5 by from Results! I got this as a TSV and love the results. However the night cream seems to separate and comes out as part liquid part cream. I've tried shaking the tube but no change. Love it except for that.
Date published: 2017-03-18
Rated 5 out of 5 by from Excellent results I love this cream and won't be without it. It has made a drastic change in the texture, firmness and radiance of my face. The scent may not be the best but it soon dissipates, besides, the results are worth putting up with the odor for a little while. Please never stop making this cream.
Date published: 2017-02-25
Rated 5 out of 5 by from Worth every penny. Yes, it's expensive. But, it's a remarkable product that delivers for me. Wrinkles and fine lines are not my real issue; mine has been a battle with a patch of melasma on my cheek that appeared about a year ago when I went outside without enough SPF. It just wouldn't fade. I've also been frustrated by a lack of glow despite using prescription creams to speed up cell turnover and collagen growth. I've used this cream faithfully day and night (I add a squirt of SPF to it during the day) for about a month, and that patch of brown on my cheek is gone. Just flat out gone. I'm guessing it was already fading but there's no denying that this product seems to have helped. And, my skin glows like it's lit from within. I've been a fan of Cold Plasma for years, and have now added this to my arsenal. I do wish that Perricone could formulate this exact product with SPF for daytime use! I am on auto-delivery.
Date published: 2016-11-06
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