Perricone MD Neuropeptide Deep Wrinkle Serum 1oz.


What is it: A fast-acting serum that contains Dr. Perricone's advanced technology to help improve the appearance of deep lines and wrinkles while helping to improve skin texture.

Who is it for: Anyone who is concerned about or has advanced signs of aging, specifically deep wrinkles.

Why is it different: Deep Wrinkle Serum works by delivering immediate benefits to the appearance of skin by helping to smooth the look of lines and wrinkles.

How do I use it: Apply two to four drops on targeted areas of the face where deep wrinkles exist, including the nasal labial lines, outer areas of the eye, upper areas of the lips, between the eyes, and on the forehead.

For Perricone MD skin-care routine: Apply after toner and before any other treatments or moisturizers.

From Perricone MD.

  • Net weight 1 oz

Tune in to QVC for Perricone MD Cosmeceuticals

Saturday, June 4, 2016 from Midnight – 1 a.m., 3 – 4 a.m., 6 – 7 a.m., 3 – 4 p.m., 6 – 7 p.m., 9 – 10 p.m., 11 p.m. – Midnight ET

Aqua (Water), Glycerin, Ethoxydiglycol, Hesperidin Methyl Chalcone, Phenoxyethanol, Dimethyl MEA (DMAE), Phosphatidylcholine, Glycolic Acid, Ascorbyl Glucoside, Caprylyl Glycol, Steareth-20, Sorbic Acid, Dipeptide-2, Acetyl Tetrapeptide-5, Pentapeptide-18, Acetyl Hexapeptide-8, Palmitoyl Tetrapeptide-7, Parfum (Fragrance)
About Dr. Perricone
Dr. Perricone

Meet Dr. Perricone

Nicholas V. Perricone, M.D. is a board-certified dermatologist, world-renowned anti-aging expert, award-winning inventor, educator, philanthropist, and creator and host of a series of public television specials which aired nationally on PBS-TV. He is also the author of five The New York Times Best Sellers, three of which achieved No. 1 status including The Wrinkle Cure, The Perricone Prescription, and The Perricone Promise.

Dr. Perricone is Adjunct Professor of Medicine at Michigan State University's College of Human Medicine. He is certified by the American Board of Dermatology, is a Fellow of the New York Academy of Sciences, and a Fellow of the American College of Nutrition. He is also a Fellow of the American Academy of Dermatology and the Society of Investigative Dermatology. Dr. Perricone has served as Assistant Clinical Professor of Dermatology at Yale School of Medicine and as Chief of Dermatology at the state of Connecticut's Veterans Hospital.

Dr. Perricone is the recipient of the Eli Whitney Award, presented by the Connecticut Intellectual Property Law Association to an outstanding individual who has made significant contributions to science, invention, and technology. Dr. Perricone is also the recipient of the American College for Advancement in Medicine (ACAM) 2000 Norman E. Clark, Sr. Lecture Award for his "dedication and contributions towards advancing complementary and alternative medicine."

He is the author of numerous scientific articles, is a contributing editor to the peer-reviewed medical journal Skin and Aging, and is a member of the editorial board of Archives of Gerontology & Geriatrics. He has contributed a chapter on antioxidants and aging for Skin Diseases in the Elderly, a recent textbook written by scientists from Stanford University.

Dr. Perricone is internationally recognized as a preeminent scientific expert in the fields of health, beauty, and anti-aging.

Information supplied by Nicholas V. Perricone, M.D.

Delivery Date Estimate

Share this Product

Reviews & Community QA

Rated 3.2 out of 5 by 100 reviewers.
Rated 5 out of 5 by Amazing ! It really does work! Buy this I have been using Perricone Neuropeptide Facial cream for about 5 yeas and I am now 67 years old. It worked beautifully for a while but I was loosing the race against aging sagging wrinkled skin. So I decided to add a serious serum that was in the mid price range of his products. This did it !!! My nasal folds down to my chin shrunk ! Yes They just withdrew. The wrinkles above my lips also reduced to almost being gone. I returned all the others, Denese, Roth, Philosophy. and re-ordered an even more expensive serum . His latest. What ever you can afford do it! I needed to know that my investment would pay off and it did. I will order this one also to use with my other Perricone products. Quit looking everywhere else. It really is a miracle before your eyes. It took about 3 weeks to see a remarkable difference. 08-27-15
Rated 5 out of 5 by Best Wrinkle Product on Market I have tried most wrinkle products out there. I have always thought this brand's neuropeptide products work better than any others, but this product is unbelievable. I have really deep 11 lines between my eyes, and using this once a day for 4 to 5 days all but makes them disappear. Same for the upper lip lines. This is the one product that I make sure never to run out of and use no matter what other products I am using or trying out. Highly, highly recommend. 01-19-15
Rated 5 out of 5 by Great Spot Treatment This reminds me of a product by the Canadian lab that works like a topical botox effect serum to relax the skin where repetitive movement lines appear. I use a mere drop per application and apply to my '1', smile lines near my eyes, rows of diagonal lines (not nasal labial folds)between my nose and lips, and the corners of my mouth. The diagonal lines have been there since my mid twenties, and 25 yrs later the lines are no deeper than they were then.What it does is relax the skin to smooth the creases to lessen the impact of repetitive facial movements. I use it at night so my lines are relaxed while I sleep. I use it in the morning and when I go out to soften lines. About halfway through my first bottle I noticed that even the most noticeable lines were barely visible. Combined with Tatcha cleanser p, Perricone facial firming moisturizer and argan oil, my skin is silky and smooth. Recently added Nuface and now have a firmer foundation to my skin as well. 11-15-14
Rated 5 out of 5 by This Is Perricone Skin-care At Its Finest! Yep- can't get around the fact that it's very expensive, but used with his evening repair cream? Oh boy!! It does everything it says and more. The pronounced lines ( that only recently made their debut appearance) are visibly reduced, and is not irritating. Get it if you can swing it. QVC how about this with the Evening repair and a HYDRATING eye cream in a kit??? As a TSV? Dr. Perricone, sometimes I think your philosophy is better looking skin through dehydration.... 11-11-14
Rated 4 out of 5 by May Not Work For Everyone.. I received this in one of the very first kits I purchased from QVC, quite some time back. I use as spot treatment and it's amazing how long this little bottle lasts! I know at the time I was about 56 or 57 - I'm 59 now.This worked well for me. Let me explain, I wouldn't describe my wrinkles as deep. My soft 1 (not 11) line- the furrow between the brows softened dramatically. It didn't work quite as well for the lower part of my face.. those tiny very fine lines from mouth to chin, which I blame on losing my back molars and waiting on dental implants. You must have your teeth to support your face or it will sink in and/or start developing fine lines. I must make more of an effort on those areas, as I try so many other products and forget I have this little gem in a corner of a dark cool drawer.Not all products work for everyone, but it's SO worth the 30 day test. I didn't really stick with it so diligently, as I'm only on my second bottle... but wouldn't want to be without it.!! Seriously, if you don't try you'll never know. I happen to think it's the best product Perricone sells besides the night-time product with Retinol, which of course takes longer to see results. Good luck to those who give this a go! :) 06-22-14
Rated 5 out of 5 by PERRICONE'S BEST PRODUCT EVER IN MY OPINION I love this deep wrinkle serum...I can feel my skin tighten as soon as I put it on. If I look away and then look back at my skin after the serum dries, I see an immediate, youthful glow as well as a firmer look. As far as I am concerned, this is Dr. Perricone's best product. I think it is a sleeper because it is not always presented but I love it! I am now purchasing it for the 6th time. Thank you QVC for selling this product. I use some of Dr. Perricone's other products but his is by far, my favorite! 06-13-14
Rated 4 out of 5 by Super Product Bought this after it was featured in some magazines. I love this product! 08-15-13
Rated 1 out of 5 by DISAPPOINTING I couldn't wait to get this home and try it. The TV representation of it made it sound fabulous. I have now been using it for several weeks, and wanted to make sure I followed the instructions exactly so that I wouldn't be stuck with it if it didn't work. AND it didn't. I have to say it has an instant effect, but not long lasting. I thought the product was more of a build-up effect that would continue to "better" my fine and deep lines and wrinkles. After about an hour I look the same as before putting the product on. Sadly it is going back, but I want SOMETHING that will work so I'll keep watching and trying. 03-29-12
  • 2016-05-29 T07:54:51.383-05:00
  • bvseo_lps, prod_bvrr, vn_prr_5.6
  • cp-1, bvpage1
  • co_hasreviews, tv_100, tr_100
  • loc_en_US, sid_A87563, prod, sort_default
MORE REVIEWS>> 2 3 4 5 ... 13

Let's Stay in Touch

* *You're signing up to receive QVC promotional email.
Connect with Us

The scoop on everything Q, from helpful tips to interesting tidbits, questions, answers, and more.

QVC is not responsible for the availability, content, security, policies, or practices of the above referenced third-party linked sites, nor liable for statements, claims, opinions, or representations contained therein. QVC's Privacy Statement does not apply to these third-party web sites.

© 1995–2016 QVC, Inc. All rights reserved. Trademark Notice

Desktop View Mobile View