Perricone MD Neuropeptide Top Sellers Duo

Perricone MD Neuropeptide Top Sellers Duo
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What is it: A two-step skin care system with extraordinary results! This powerhouse duo works together to provide both instant and long-term benefits.

Who is it for: Anyone looking to improve the appearance of deep lines and wrinkles and skin tone, leaving their complexion looking healthy and radiant.

Why is it different: This powerful duo goes to work improving the appearance of deep lines and wrinkles immediately and provides benefits with continued use.

How do I use it: Dr. Perricone recommends applying Neuropeptide Deep Wrinkle Serum on cleansed skin. Apply two to four drops on fingertips and massage on entire face or targeted areas.

Follow with Neuropeptide Firming Moisturizer. If using other treatment products, apply before Neuropeptide Firming Moisturizer.

From Perricone MD.


  • 1-oz Neuropeptide Deep Wrinkle Serum
  • 2-oz Neuropeptide Firming Moisturizer

Delivery Date Estimate

Reviews & Community QA

Perricone MD Neuropeptide Top Sellers Duo is rated 4.1 out of 5 by 13.
Rated 1 out of 5 by from Does not work I assumed that expensive products like this would work. But there was no visible difference after weeks of use. I will not buy from this line again.
Date published: 2016-12-28
Rated 1 out of 5 by from It's not looking very promising I once heard "there is no face cream that is going to get rid of wrinkles". So far Unfortunately, I have found this to be true after thousands of dollars worth of creams that are all part of that infamous "graveyard of creams". Unfortunately so far this one looks like it too would be added to that graveyard, however for the price of this stuff, it's going back if I don't see at least some change soon. You would think I would learn. This was my last hope. Botox or surgery is looking better and better. I might just as well start saving my money and do something I know will work instead of wasting it on these constant letdowns and false promises of magic face creams! Sorry but I truly believe It's just not going to happen!
Date published: 2016-06-06
Rated 5 out of 5 by from Neuropeptides a 10 For about the past eighteen months there has been a parade of skin care products through my bathroom, for wrinkles, elasticity, and firmness, that I have used, all higher end products, and have decided the neuropeptides are the best!!!!. I just Turned 65 and the peptides, to me, address the type of skincare needed for my age. I also recommend the acyl glutathione deep crease and eyelid serums, and Cold plasma sub D for the neck area, for targeted treatments .At one time had purchased over 10 different products in my trial, error, and research, I have sene better results with the Peptides. It is a little pricey but a little goes a long way. Have always taken care of my skin and used skin care serums since in my 30's. To me these work the best for my later in life crisis.
Date published: 2014-05-30
Rated 1 out of 5 by from Completely Disappointed :( I was extremely disappointed with these products...I have watched Perricone on QVC and elsewhere and couldn't wait to try them. The 3 easy payments allowed me to do so HOWEVER $300 plus dollars for products that made no difference in my skin is just a waste of money. Don't know about you but water would have done the same. I tried to give it more than a month thinking perhaps it would take a little longer to show results...still...nothing! Too late to return now. What to do???
Date published: 2014-05-29
Rated 5 out of 5 by from Great Product After I cleanse my skin and put these products on, my skin looks healthy. Worth every penny.
Date published: 2014-02-17
Rated 5 out of 5 by from Was Time For A Change I've been a faithful user of all things Philosophy for years..I mean years but started noticing my skin is stalling out, its just not working for me anymore. Started noticing lines and wrinkles that my WHINE Serum and moisturizer just couldn't manage. I bought these items separately, gave them a full 4 weeks using only in the AM. Now while my face isn't completely transformed those new lines and wrinkles are clearly softer using the PMD serum...Something I also noticed after the 4 weeks my skin tone has almost completely evened out where after using all things philosophy my skin NEVER completed made me "Makeup Optional" I admit I was blessed with nice skin, but it isn't perfect and did need help and maintaining. I am insanely impressed with the serum. Now the Moisturizer, after 4 weeks of use my skin is SO much firmer, but what I found with this moisturizer was an immediate feeling of firmness, that feeing didn't last throughout the day, but as the weeks went by my skin was firmer and firmer. I ran into an x-coworker I haven't seen in over 2 years, she said "well you look younger what ya do" <==assuming I'd had Botox maybe? I just kinda laughed and said "Expensive Skincare Products" Yes, PMD are $$ but when you find a product that can change your skin and continue to see improvement as the weeks go by its worth it to me. After the recent Perricone shows I went searching and found this duo and was thrilled and ordered it. I have not used any other items from Perricone but I did order the TSV with the OVM and Photo Plasma and looking forward to adding these into my regimen...Im starting slow but I do highly recommend this lovely duo.
Date published: 2014-01-13
Rated 5 out of 5 by from This may be it I have been using for 4 days and I see something. I will continue to use for the 30 days and will report in after 20. I am taking a pic each day with my I pad, yikes!
Date published: 2013-06-22
Rated 5 out of 5 by from Love it! These products are absolutely wonderful! They make your skin feel great!!!! When you feel great , you look great.I've had people to stare ..so I know that others are noticing my new look & trying to figure out if I've had a face lift..lol....I recommend this to any woman that wants to see and feel the change in their skin! 5 stars from me!!
Date published: 2013-02-07
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