Perricone MD Neuropeptide Night Cream

Perricone MD Neuropeptide Night Cream
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What is it: Neuropeptide Night Cream helps address the appearance of wrinkles, helps hydrate skin, softens skin's texture, and helps reduce the look of dry lines.

Who is it for: Anyone looking to help address the appearance of dry lines and wrinkles and help hydrate skin.

Why is it different: Dr. Perricone wanted to create what he refers to as one of his "ultimate tools" for addressing the appearance of wrinkles. He formulated it by using Neuro Oligopeptide Complex, which is formulated with six different neuropeptides. He combined this with other keynote technologies.

In a consumer study, after four weeks of use, 83% reported an improvement in the appearance of fine lines and 83% saw improvement in the appearance of overall lines and wrinkles.

How do I use it: Neuropeptide Night Cream should always be your last product before you apply a moisturizer. You only need a dime-size amount, because it's heavily concentrated. Massage it into the skin to activate it. Apply it up under the chin and jawline. Continue to massage it up behind the ears and around the eye area.

From Perricone MD.


  • 1-fl oz Neuropeptide Night Cream

Delivery Date Estimate

Reviews & Community QA

Rated 3.7 out of 5 by 3 reviewers.
Rated 5 out of 5 by Great Scent, Silky Feel I received a sample in one of the QVC beauty boxes that incidentally was only have the cost of this single product and included some other products I use routinely. Although I already have a pretty thorough skin regimen, I opted to add this in. For starters, this cream is very concentrated and a very small amount really does go a long way! (You've never heard that before, right?) This time it's actually true. The scent is subtle, extremely soothing, and spa-like, and almost worth applying on its merit alone. But the way it feels on your skin is amazing...very silky, rich, and not at all greasy. My skin instantly drank it in, especially around my eyes. Even better was the way it made my skin look and feel! The delicate area around my eyes was visibly more hydrated and plump even after my first use. I haven't used it long enough to speak to its long-term efficacy, but I will definitely be continuing to include this nightly. I am a pretty dedicated Isomers user, but plan to do more research on Perricone products thanks to this lovely cream. 01-01-17
Rated 1 out of 5 by Disappointed I purchased the packaged trio that included Neuropeptide Night Cream, Cold Plasma Sub D, and Face Finishing Moisturizer. The Neuropeptide Night Cream gave my skin wide red streaks across my face and neck with burning where the streaks appeared. Very unpleasant!! No side effects from the Cold Plasma Sub D (which I've used in the past with no significant improvement, but I'll give it another chance). No side effects from the Face Finishing Moisturizer (which smells like rose water) and no real improvement in my skin. 10-03-16
Rated 5 out of 5 by Love Neuropeptides I've been using Perricone MD Neuropeptide products for many years now and the Night Cream is a great addition to my routine. I always start with Cold Plasma then add the Neuropeptide facial (day) or night cream, then finish with the Neuropeptide Firming Moisturizer. Great results. 02-09-16
  • 2017-01-23 T12:35:37.641-06:00
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