Perricone MD Neuropeptide Night Cream 2.5 oz.

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The One You've Been Seeking

"Dr. Perricone has done it again! He's created a product, years in the making, that no other Perricone product has ever been able to do... Dr. Perricone is using six new neuropeptides he hasn't used in any other product. This is the answer you've been waiting for to address those wrinkles."

—Dana Bledsoe

What is it: Neuropeptide Night Cream helps address the appearance of wrinkles, helps hydrate skin, softens skin's texture, and helps reduce the look of dry lines.

Who is it for: Anyone looking to help address the appearance of dry lines and wrinkles and help hydrate skin.

Why is it different: Dr. Perricone wanted to create what he refers to as the "ultimate tool" for addressing the appearance of wrinkles. He formulated it by using Neuro Oligopeptide Complex, which is formulated with six different neuropeptides. He combined this with other keynote technologies, along with his unique delivery system.

After four weeks of use in a consumer study, 83% reported an improvement in the appearance of fine lines and 83% saw improvement in the appearance of overall lines and wrinkles.

How do I use it: Neuropeptide Night Cream should always be your last product before you apply a moisturizer. You only need a dime-sized amount, because it's heavily concentrated. Massage it into the skin to activate it. Apply it up under the chin and jawline. Continue to massage it up behind the ears and around the eye area.

From Perricone MD.


  • 2.5-fl oz Neuropeptide Night Cream

Tune in to QVC for Perricone MD Cosmeceuticals

Saturday, February 25, 2017 from Midnight – 1 a.m., 3 – 4 a.m., 3 – 4 p.m., 6 – 7 p.m., 9 – 10 p.m., 11 p.m. – Midnight ET

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Reviews & Community QA

Perricone MD Neuropeptide Night Cream 2.5 oz. is rated 3.6 out of 5 by 82.
Rated 5 out of 5 by from Worth every penny. Yes, it's expensive. But, it's a remarkable product that delivers for me. Wrinkles and fine lines are not my real issue; mine has been a battle with a patch of melasma on my cheek that appeared about a year ago when I went outside without enough SPF. It just wouldn't fade. I've also been frustrated by a lack of glow despite using prescription creams to speed up cell turnover and collagen growth. I've used this cream faithfully day and night (I add a squirt of SPF to it during the day) for about a month, and that patch of brown on my cheek is gone. Just flat out gone. I'm guessing it was already fading but there's no denying that this product seems to have helped. And, my skin glows like it's lit from within. I've been a fan of Cold Plasma for years, and have now added this to my arsenal. I do wish that Perricone could formulate this exact product with SPF for daytime use! I am on auto-delivery.
Date published: 2016-11-06
Rated 5 out of 5 by from beautiful complexion I have been using this product for over 4 years now and it does exactly what it says it will. I have received complements about how pretty my skin is.
Date published: 2016-10-05
Rated 3 out of 5 by from Outside Tube Packaging I am on auto delivery for the day and night Neuropeptide Night Creams. When you get to the end of the products the white or brown on the cream tube packaging flakes off. This should not happen and it can easily get onto your face. My hands are clean when I close up the product so please work on this. Otherwise I like the creams.
Date published: 2016-09-20
Rated 5 out of 5 by from Misplaced temporarily and I missed out I had misplaced this part of a special I ordered. Now I wish I had auto delivery. My skin looked so smooth in the a.m. I decided to actually use it more faithfully with both day and night products, and am searching for another deal, or way to get both day and night cream together. If One night produced those results, I need more. I'm a hit or miss user of products, and this will actually make me use it nightly too - faithfully.
Date published: 2016-09-13
Rated 5 out of 5 by from Amazing. I was skeptical as nothing worked. Perricone products are AMAZING! Worth every penny and more. Thank you QVC for a great price and to Dr Perricone for a product that works miracles.
Date published: 2016-08-11
Date published: 2016-08-10
Rated 5 out of 5 by from WOW! I should start by saying that I have had these products for a week but due to Lupus & other health issues I have zero energy & haven't used them faithfully twice a day. I was even going to cancel the order or return them due to the cost. My neck is a mess! Neck surgery in January on top of wrinkles & burns from too much radiation when the Dr. "nuked" my thyroid. After just a week I barely recognize myself in the mirror! The wrinkles on my neck & chest are 80% better already & my face is incredibly soft & truly hydrated! I am so inspired that I have vowed to FORCE MYSELF to use the products twice a day. Nothing is better when you feel awful than looking in the mirror and looking younger! Thank you QVC & Dr. P.!
Date published: 2016-06-20
Rated 5 out of 5 by from OVERNIGHT SENSATION The results were unbelievable after only one application. If I did not experience it for myself I would not believe the results either. This is an amazing product for firming even the jawline as well as the under-eye area! A little goes a long way as with all of the Dr.'s formulas. When you break it down to $40 a month for this calibre of result this product is in line with most of the other less efficacious products I have used. Can't wait to see the cumulative results. My vote would be for a TSV with both the Day and Night Neuropeptide Creams and the Conformer even if it were just one ounce of each instead of the regular sizes. What a triple threat to aging that would make! I can't thank Dr. Perricone enough for such stellar products.
Date published: 2016-05-12
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