Perricone MD Neuropeptide Night Cream 2.5 oz.

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The One You've Been Seeking

"Dr. Perricone has done it again! He's created a product, years in the making, that no other Perricone product has ever been able to do... Dr. Perricone is using six new neuropeptides he hasn't used in any other product. This is the answer you've been waiting for to address those wrinkles."

—Dana Bledsoe

Application Protocol

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What is it: Neuropeptide Night Cream helps address the appearance of wrinkles, helps hydrate skin, softens skin's texture, and helps reduce the look of dry lines.

Who is it for: Anyone looking to help address the appearance of dry lines and wrinkles and help hydrate skin.

Why is it different: Dr. Perricone wanted to create what he refers to as the "ultimate tool" for addressing the appearance of wrinkles. He formulated it by using Neuro Oligopeptide Complex, which is formulated with six different neuropeptides. He combined this with other keynote technologies, along with his unique delivery system.

After four weeks of use in a consumer study, 83% reported an improvement in the appearance of fine lines and 83% saw improvement in the appearance of overall lines and wrinkles.

How do I use it: Neuropeptide Night Cream should always be your last product before you apply a moisturizer. You only need a dime-sized amount, because it's heavily concentrated. Massage it into the skin to activate it. Apply it up under the chin and jawline. Continue to massage it up behind the ears and around the eye area.

From Perricone MD.


  • 2.5-fl oz Neuropeptide Night Cream

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A252416 — Perricone MD Neuropeptide Night Cream 2.5 oz.

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a252416_ingredients.html A252416 Neuropeptide Night Cream

Ingredients: Water/Aqua/Eau, Glycerin, Isononyl Isononanoate, Pentaerythrityl
Tetraethylhexanoate, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, C12-20
Acid PEG-8 Ester, Dimethyl Isosorbide, C10-18 Triglycerides, Isodecyl Salicylate,
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Butylene Glycol,
Squalane, C12-15 Alkyl Benzoate, Dimethicone, Polymethyl Methacrylate, Dimethyl
MEA, Citric Acid, Phenoxyethanol, Fragrance/Parfum, Caprylyl Glycol, Tribehenin,
Coco-Glucoside, Polysorbate 60, Tyrosine, Pentylene Glycol, Potassium Sorbate,
Tocopheryl Acetate, Dipotassium Glycyrrhizate, Hesperidin Methyl Chalcone, Hexylene
Glycol, Ceramide 2, Sodium Hydroxide, Urea, Fructose, PEG-10 Rapeseed Sterol,
Disodium EDTA, Steareth-20, Allantoin, Trehalose, Sodium Lactate, Sodium Chloride,
Sodium PCA, Maltose, Acetyl Hexapeptide-8, Pentapeptide-18, Tetrapeptide-21,
Glucose, Sodium Hyaluronate, Dipeptide-2, Palmitoyl Tetrapeptide-7, Palmitoyl

Information provided by Perricone MD

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Rated 3.9 out of 5 by 33 reviewers.
Rated 5 out of 5 by OVERNIGHT SENSATION The results were unbelievable after only one application. If I did not experience it for myself I would not believe the results either. This is an amazing product for firming even the jawline as well as the under-eye area! A little goes a long way as with all of the Dr.'s formulas. When you break it down to $40 a month for this calibre of result this product is in line with most of the other less efficacious products I have used. Can't wait to see the cumulative results. My vote would be for a TSV with both the Day and Night Neuropeptide Creams and the Conformer even if it were just one ounce of each instead of the regular sizes. What a triple threat to aging that would make! I can't thank Dr. Perricone enough for such stellar products. 05-11-16
Rated 5 out of 5 by Wonderful (but oh so expensive!) I received a sample jar of this, and I'm already panicking about having to purchase the incredibly expensive 2.5 oz tube. I don't know why it's such an exorbitant price, but that aside, the product is indeed wonderful. At first, I didn't want to add an extra step to my night-time routine. This cream is not a moisturizer, so we need to add a moisturizer on top of it. The instructions are to put on your serum(s) first, then this, then a moisturizer. For me, this additional step has ultimately proved worth it. My skin was dehydrated for a while, and fine lines really show up on dry skin. I was also losing elasticity and firmness. I used up two jars of Algenist before, and it didn't do much for me, so I tried this. The additional step of this cream has plumped up my skin overnight, and somehow added to the moisturization power of my moisturizer. My fine lines are smoothed over and my skin is well and truly plumped up. I am really impressed. I don't know if I can purchase a $300 tube, though, so these results are short-lived, relegated only to the lifespan of my sample jar. :( For those who can afford it, lucky you! 05-08-16
Rated 3 out of 5 by On the fence As a user of Dr P's neuropeptide Conformer and Day cream I was excited to purchase the special offer of the night cream. Upon applying the product, my skin immediately reacted it began to burn and become red. (I have not had that particular reaction to any of his other products) Sorry it is going back. Love the other products mentioned. 04-01-16
Rated 1 out of 5 by Over rated & over priced In order to give this product a true test so I used it faithfully every night for 6 months. There was no significant change in my skin. It is highly over rated and over priced. I cancelled my auto delivery. 12-28-15
Rated 5 out of 5 by Get ready to get carded! Another homerun from Dr. Perricone. My skin wakes up refreshed, with improved clarity and what wrinkles? Yes- it's expensive, but the Q has great offers and easy pay to make it affordable for the rest of us. If you are looking for a night treatment, not another thick night cream, this is it. The skin drinks it and wakes up 5 yrs younger. I wish he would have something like this for the rest of the body. Dr. P is ahead of his time! 10-07-15
Rated 5 out of 5 by Youth in a Tube This is hands down one of my favorite Perricone products. I've used Perricone for 8 plus years now.. For those who complain the night cream is runny, it really shouldn't be! It should come out very creamy & uniformly- like soft toothpaste.. The smell is not off-putting & the texture is just right for my normal skin. I apply after I use my serums. This product has single handedly taken my skin to a whole new level and knocked 10 plus years off when used faithfully.. Like I said, staying true to you regimine is key. Yes, I started with good genes, but my problem areas have vanished. I ordered this as part of the TSV with the Neuropeptide Day face cream, which is Dana's holy grail. This cream *does* need to be shaken a bit as the consistency isn't as visceral as the night version, but it shouldn't be watery either. I can see why she loves it so much. Do follow her instructions for all creams and Perricone formulas. Bring them up and behind the ears, gently massaging into the skin. My skin definitely has a youthful glow, is makeup optional, and most impressive are the stubborn fine lines are greatly diminished. I don't use Perricone exclusively, but the products I do use actually perform. Would you expect to pay a bargain price for any doctor who can practice plastic surgery? Of course you wouldn't. No it's not cheap, but it's also a result of hours upon hours of research and more expensive ingredients.. I know the cost of pharmaceutical grade DMAE through a compounding pharmacy... and the neuropiptides certainly aren't cheap. You're also paying for the formulators knowledge and time put into into creating the most optimal products- It doesn't compare to the Olay products. This is a case where you get what you pay for. But realistically not all products work the same for everyone. I would ask yourself- have you really dedicated your usage to 7 days & nights a week for at least 4 weeks? Until you do you may just be amazed by how dramatically dedication pays off. 60 yrs old never looked so good. I'm more than pleased! This are power packed formulas ladies. 09-11-15
Rated 5 out of 5 by Very Happy I am 64 years old and this is the best night cream I ever used. Every morning I look into the mirror my face and skin look so youthful since I used this cream. I don't see the fine lines near my eyes anymore like I used to every morning. Thank you Dr. Perricone for making this cream. 08-18-15
Rated 5 out of 5 by Great night cream I got this is the duo set and this night cream feels great. I have noticed an improvement in my skin's moisture and firmness. I have not had any issues with separation with the night cream but have with the day cream. 08-15-15
Rated 5 out of 5 by Worth it! I recommend using this with the Neuropeptide Day Cream. I noticed a decrease in my deep wrinkle across the bridge of my nose and the "parenthesis" shaped lines one either side of my mouth in about a week. My co-worker told me my skin was "glowing" after using the Day and the Night for a month. I only use a pea size amount and although the cream feels "heavy" it absorbs quickly and leaves my skin feeling hydrated and not greasy. I have combination skin so I am concerned about the texture and feel of night creams. 08-06-15
Rated 5 out of 5 by A Keeper This is the TRUE Liquid Gold. Oh my Gosh!!!! So nourishing, moisturizing. My face immediately responded to this night cream after the first night!!!! I use many Perricone products but this tops them ALL. Love, Love, Love this. I hesitated for quite some time because of the price but nothing will hold me back now just do easy pay. My face looks radiant and nourished (can't stop using that word). I can't explain it but when I look at myself in the mirror I see a difference. Don't hesitate, try it. 12-02-14
Rated 5 out of 5 by Preview Your Review I decided I would test this product for 6 months before coming to a conclusion about - or writing a review. After 6 months I can definitely say it did everything that I wanted it to do. I have had two deep lines one on either side of my mouth - one lines is almost gone entirely and the other is not very deep and although noticeable much less so. The product easily lasts for six months. I am looking forward to the next six months and see what happens. 10-10-14
Rated 5 out of 5 by Worth Every Penny Perricone MD Neuropeptide Night Cream is wonderful. A little goes a long way. I see and feel instant results. I awake in the morning with beutiful, younger looking skin. I have nothing but praise for this product. Pair it with the Perricone MD Neuropeptide Firming Moisturizer for a doubly dramatic effect. It is awesome. 09-23-14
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