Perricone MD Neuropeptide Night Cream 2.5 oz.

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The One You've Been Seeking

"Dr. Perricone has done it again! He's created a product, years in the making, that no other Perricone product has ever been able to do... Dr. Perricone is using six new neuropeptides he hasn't used in any other product. This is the answer you've been waiting for to address those wrinkles."

—Dana Bledsoe

What is it: Neuropeptide Night Cream helps address the appearance of wrinkles, helps hydrate skin, softens skin's texture, and helps reduce the look of dry lines.

Who is it for: Anyone looking to help address the appearance of dry lines and wrinkles and help hydrate skin.

Why is it different: Dr. Perricone wanted to create what he refers to as the "ultimate tool" for addressing the appearance of wrinkles. He formulated it by using Neuro Oligopeptide Complex, which is formulated with six different neuropeptides. He combined this with other keynote technologies, along with his unique delivery system.

After four weeks of use in a consumer study, 83% reported an improvement in the appearance of fine lines and 83% saw improvement in the appearance of overall lines and wrinkles.

How do I use it: Neuropeptide Night Cream should always be your last product before you apply a moisturizer. You only need a dime-sized amount, because it's heavily concentrated. Massage it into the skin to activate it. Apply it up under the chin and jawline. Continue to massage it up behind the ears and around the eye area.

From Perricone MD.


  • 2.5-fl oz Neuropeptide Night Cream

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Reviews & Community QA

Rated 4.1 out of 5 by 38 reviewers.
Rated 5 out of 5 by Worth every penny. Yes, it's expensive. But, it's a remarkable product that delivers for me. Wrinkles and fine lines are not my real issue; mine has been a battle with a patch of melasma on my cheek that appeared about a year ago when I went outside without enough SPF. It just wouldn't fade. I've also been frustrated by a lack of glow despite using prescription creams to speed up cell turnover and collagen growth. I've used this cream faithfully day and night (I add a squirt of SPF to it during the day) for about a month, and that patch of brown on my cheek is gone. Just flat out gone. I'm guessing it was already fading but there's no denying that this product seems to have helped. And, my skin glows like it's lit from within. I've been a fan of Cold Plasma for years, and have now added this to my arsenal. I do wish that Perricone could formulate this exact product with SPF for daytime use! I am on auto-delivery. 11-06-16
Rated 5 out of 5 by Misplaced temporarily and I missed out I had misplaced this part of a special I ordered. Now I wish I had auto delivery. My skin looked so smooth in the a.m. I decided to actually use it more faithfully with both day and night products, and am searching for another deal, or way to get both day and night cream together. If One night produced those results, I need more. I'm a hit or miss user of products, and this will actually make me use it nightly too - faithfully. 09-13-16
Rated 5 out of 5 by Amazing. I was skeptical as nothing worked. Perricone products are AMAZING! Worth every penny and more. Thank you QVC for a great price and to Dr Perricone for a product that works miracles. 08-11-16
Rated 5 out of 5 by WOW! I should start by saying that I have had these products for a week but due to Lupus & other health issues I have zero energy & haven't used them faithfully twice a day. I was even going to cancel the order or return them due to the cost. My neck is a mess! Neck surgery in January on top of wrinkles & burns from too much radiation when the Dr. "nuked" my thyroid. After just a week I barely recognize myself in the mirror! The wrinkles on my neck & chest are 80% better already & my face is incredibly soft & truly hydrated! I am so inspired that I have vowed to FORCE MYSELF to use the products twice a day. Nothing is better when you feel awful than looking in the mirror and looking younger! Thank you QVC & Dr. P.! 06-20-16
Rated 5 out of 5 by OVERNIGHT SENSATION The results were unbelievable after only one application. If I did not experience it for myself I would not believe the results either. This is an amazing product for firming even the jawline as well as the under-eye area! A little goes a long way as with all of the Dr.'s formulas. When you break it down to $40 a month for this calibre of result this product is in line with most of the other less efficacious products I have used. Can't wait to see the cumulative results. My vote would be for a TSV with both the Day and Night Neuropeptide Creams and the Conformer even if it were just one ounce of each instead of the regular sizes. What a triple threat to aging that would make! I can't thank Dr. Perricone enough for such stellar products. 05-11-16
Rated 5 out of 5 by Wonderful (but oh so expensive!) I received a sample jar of this, and I'm already panicking about having to purchase the incredibly expensive 2.5 oz tube. I don't know why it's such an exorbitant price, but that aside, the product is indeed wonderful. At first, I didn't want to add an extra step to my night-time routine. This cream is not a moisturizer, so we need to add a moisturizer on top of it. The instructions are to put on your serum(s) first, then this, then a moisturizer. For me, this additional step has ultimately proved worth it. My skin was dehydrated for a while, and fine lines really show up on dry skin. I was also losing elasticity and firmness. I used up two jars of Algenist before, and it didn't do much for me, so I tried this. The additional step of this cream has plumped up my skin overnight, and somehow added to the moisturization power of my moisturizer. My fine lines are smoothed over and my skin is well and truly plumped up. I am really impressed. I don't know if I can purchase a $300 tube, though, so these results are short-lived, relegated only to the lifespan of my sample jar. :( For those who can afford it, lucky you! 05-08-16
Rated 3 out of 5 by On the fence As a user of Dr P's neuropeptide Conformer and Day cream I was excited to purchase the special offer of the night cream. Upon applying the product, my skin immediately reacted it began to burn and become red. (I have not had that particular reaction to any of his other products) Sorry it is going back. Love the other products mentioned. 04-01-16
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