Perricone MD High Potency AM/PM Duo

Perricone MD High Potency AM/PM Duo
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What is it: A revolutionary two-piece treatment system engineered with Dr. Perricone's three signature ingredients of DMAE, alpha lipoic acid, and vitamin C ester, coupled with his unique delivery system.

Who is it for: This regimen is for anyone who wants to help address the appearance of the signs of aging.

Why is it different: Dr. Perricone's three keynote technologies help to deliver amazing benefits. In a consumer use study, when using the High Potency Evening Treatment, 100% of subjects noticed an improvement in their skin texture/smoothness; 93% reported an improvement in skin firmness, tone, luminosity, and lines and wrinkles; 97% reported their skin appeared more radiant, appeared healthier, and more renewed; 90% of subjects noticed an improvement in the appearance of lines and wrinkles within the first five minutes of application; and 93% saw continued improvement in the appearance of lines and wrinkles overall.

In a consumer use study, when using the High Potency Amine Face Treatment, after four weeks of use, 80% reported continued improvement in the appearance of fine lines and wrinkles overall.

How do I use it: Apply the High Potency Amine Face Treatment in the morning on the face and neck in gentle circular motions.

Apply the High Potency Evening Treatment in the evening on the face and neck in gentle circular motions. Follow with any Perricone MD moisturizer (not included) if skin feels unusually dry.

From Perricone MD.


  • 2-oz High Potency Amine Face Treatment
  • 2-oz High Potency Evening Treatment

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Reviews & Community QA

Rated 4 out of 5 by 9 reviewers.
Rated 5 out of 5 by Love To be honest, I never thought Perricone would be worth the price, but some of the items are, for me--it is probably different for everyone. I have used retinol for years--62 yrs old and just couldn't imagine a product without it working, but this does. It does work for wrinkles and lifting. A couple of the products have just done nothing for me. I will have to use some drugstore items to afford this, though. 12-08-15
Rated 5 out of 5 by Great Duo This is a winner combo for me!..They have helped with shrinking pores and my skin is smoother and some slight firming...I am so glad i lucked out and got this while it was reduced in price and on A/D other wise i could not pay 160.00. 09-30-15
Rated 5 out of 5 by So glad to see these two together! Love both these two products, please keep them packaged together.Really make a difference in my skin, clearer, brighter, and texture much better. Thank you! 05-25-15
Rated 5 out of 5 by Amazing! Firming, Toning, Brightening!! I have used this duo for over 3 years. The 2 compliment each other, whereas all skin issues are addressed. Really, these two products will DEFINATELY make a huge difference in your face. Firming, toning and brightening..... these two do that! 04-25-15
Rated 2 out of 5 by Not as good as other products in this line I'll use the bottles up, but they really don't do anything. I have other Perricone peoducts that work great, but these are not necessary in my opinion. 04-01-15
Rated 3 out of 5 by WORKS IN CONJUNCTION WITH OTHERS I have been using this duo for approximately one year. I like them a bit. I think the use of them in conjunction with my other Perricone creams has helped. However, I have decided to discontinue using them as I don't think they have done a great deal for me. They are good quality products as are all of Dr. Perricone's products. I gave a set to a friend for Christmas and am giving my remaining supply to another friend. I think they will like them. 03-03-15
Rated 5 out of 5 by Best Perricone Products I've used these two products for years- My skin is softer, more bright, and a more even tone after using these. My sun damage has been greatly reduced. I've tried other cheaper products for several months at a time to save money- every time I end up back with these two Perricone products. Only a small amount of product is needed at a time, so one bottle lasts me 4-6 months. Hope this stays on auto-delivery!! 02-24-15
Rated 5 out of 5 by wonderful duo I use both of these products and if you look at reviews for each of them their ratings by other users are very positive . Buying These together is a huge savings. I use several perricone products and if I had to choose these would be my favorites 02-23-15
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