Perricone MD High Potency AM/PM Duo

Perricone MD High Potency AM/PM Duo
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What is it: A revolutionary two-piece treatment system engineered with Dr. Perricone's three signature ingredients of DMAE, alpha lipoic acid, and vitamin C ester, coupled with his unique delivery system.

Who is it for: This regimen is for anyone who wants to help address the appearance of the signs of aging.

Why is it different: Dr. Perricone's three keynote technologies help to deliver amazing benefits. In a consumer use study, when using the High Potency Evening Treatment, 100% of subjects noticed an improvement in their skin texture/smoothness; 93% reported an improvement in skin firmness, tone, luminosity, and lines and wrinkles; 97% reported their skin appeared more radiant, appeared healthier, and more renewed; 90% of subjects noticed an improvement in the appearance of lines and wrinkles within the first five minutes of application; and 93% saw continued improvement in the appearance of lines and wrinkles overall.

In a consumer use study, when using the High Potency Amine Face Treatment, after four weeks of use, 80% reported continued improvement in the appearance of fine lines and wrinkles overall.

How do I use it: Apply the High Potency Amine Face Treatment in the morning on the face and neck in gentle circular motions.

Apply the High Potency Evening Treatment in the evening on the face and neck in gentle circular motions. Follow with any Perricone MD moisturizer (not included) if skin feels unusually dry.

From Perricone MD.


  • 2-oz High Potency Amine Face Treatment
  • 2-oz High Potency Evening Treatment

Tune in to QVC for Perricone MD Cosmeceuticals

Saturday, February 24, 2018 from Midnight – 1 a.m., 3 – 4 a.m., 2 – 3 p.m., 5 – 6 p.m., 8 – 9 p.m. ET and Sunday, March 4, 2018 from 2 – 3 a.m. ET

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Reviews & Community QA

Perricone MD High Potency AM/PM Duo is rated 4.1 out of 5 by 16.
Rated 4 out of 5 by from Great product except...... I am 61 yrs old and been using this product off and on when I can afford it. This time around I have been using it for approximately 8 months. My skin looks looks great and soft and my wrinkles have also diminished. The problem I noticed this time is that my face is always shiny after applying the product (morning and evening). I am not a big fan of face powder because powders show up my wrinkles. I will start looking for another product with same ingredients/results without the shine. Still a good product and it did help my dry skin.
Date published: 2017-08-16
Rated 4 out of 5 by from Good Duo I had purchased these two items in a winter set. The Amine Face Lift does tighten along the jaw line. I do use this before I use the Neuropeptide facial cream in the morning. It does help my aging face appear toner! The Evening repair I have learned to use once every 3 days. It does contain vitamin A which is great but my skin is a bit sensitive to it. I do believe cutting back is just fine and it is working,
Date published: 2017-01-26
Rated 5 out of 5 by from Love, Love, Love I love this duo and would love to be able to use it all the time, but I can't. I would if I could, though, and I've used all the good ones!
Date published: 2016-01-06
Rated 5 out of 5 by from Love To be honest, I never thought Perricone would be worth the price, but some of the items are, for me--it is probably different for everyone. I have used retinol for years--62 yrs old and just couldn't imagine a product without it working, but this does. It does work for wrinkles and lifting. A couple of the products have just done nothing for me. I will have to use some drugstore items to afford this, though.
Date published: 2015-12-08
Rated 5 out of 5 by from Great Duo This is a winner combo for me!..They have helped with shrinking pores and my skin is smoother and some slight firming...I am so glad i lucked out and got this while it was reduced in price and on A/D other wise i could not pay 160.00.
Date published: 2015-10-01
Rated 5 out of 5 by from So glad to see these two together! Love both these two products, please keep them packaged together.Really make a difference in my skin, clearer, brighter, and texture much better. Thank you!
Date published: 2015-05-25
Rated 3 out of 5 by from Good..but better options available I am in my 50's and was looking for a good quality product to ward off the signs of premature aging. I have used it routinely for 6 months now and I honestly cannot say that I see any difference using this product. I will admit that I see my dermatologist regularly and am using Retin A. Perhaps if I was not using a prescription medication already I may have been more impressed with the results, but in my situation, I just don't think that this is worth the price.
Date published: 2015-05-06
Rated 5 out of 5 by from Amazing! Firming, Toning, Brightening!! I have used this duo for over 3 years. The 2 compliment each other, whereas all skin issues are addressed. Really, these two products will DEFINATELY make a huge difference in your face. Firming, toning and brightening..... these two do that!
Date published: 2015-04-25
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