Perricone MD Acyl- Glutathione Deep Crease Serum, 1 oz.

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What is it: Acyl-Glutathione Deep Crease Serum is Dr. Perricone's serum to help the appearance of creases.

Who is it for: Anyone showing advanced signs of aging, including creases on the forehead, around the lips, and in the nasal-labial lines.

Why is it different: Acyl-Glutathione Deep Crease Serum contains Dr. Perricone's Acyl-Glutathione--found in any Perricone MD product. This is then combined with synergistic peptides to create his very first comprehensive and targeted serum!

It's specifically formulated to help reduce the appearance of creases caused by daily repetitive facial movements, including the horizontal ceases on the forehead, the 11-line creases between the eyebrows, the vertical creases around the lips, and the creases along the mouth in the nasal-labial lines.

In an independent consumer use study, after 30 days of use, 83% of subjects reported that their eye wrinkles and creases looked diminished; 78% reported their worry creases appeared reduced; 76% reported their frown creases appeared diminished; and, overall, 76% of subjects reported that their deep creases appeared more shallow.

How do I use it: Dr. Perricone recommends applying morning and evening by massaging Acyl-Glutathione Deep Crease Serum all over face, paying special attention to visible creases that generally appear along the forehead, between the eyebrows, and along the contours of the mouth. Please see the Application Protocol to determine how best to fit into your skin care regimen.

From Perricone MD.

  • Net weight 1 fl oz

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Reviews & Community QA

Rated 2.3 out of 5 by 67 reviewers.
Rated 5 out of 5 by OMG! After one week/10 days of using this product I saw my wrinkles disappearing. .I have tried so many products. Including Perricone's early products in search of one that actually works. (not as thrilled) This Deep Crease Serum does lessen the creases. Pricey but you don't need much and results were in one week/10 days.. I am hooked and will re review in a few. Definitely worth the value but better when you can try this with his specials and promotions. 01-18-14
Rated 5 out of 5 by best product ever!! This serum has dramatically changed the appearance of my skin. The fine lines and wrinkles are amazingly diminished and the texture of my skin is like satin. I have used Perricone for 20+ years and this is a life-changer! Give it 30 days and you will truly be amazed!! I love love love it!!!!!!!!!!!!!!!! 01-10-14
Rated 1 out of 5 by Poor quality, Doesn't work Used this product for several months. Not a change. I take photos to see if any changes showed. Don't waist your money. 12-31-13
Rated 5 out of 5 by Can't Go Without! I have tried many eye creams- from Philosophy to Caudalie to Lancôme, Sheseido and so many others over the years and nothing helps to tighten my eye area like Perricone acyl glutathione eye serum. I have tried to go without it and I just can't do it. For me- it really works. It tightens that loose eyelid area especially and I love it! 12-23-13
Rated 1 out of 5 by COMPLETELY INEFFECTIVE About the only positive thing I can say about this serum is that it is non-irritating. But after two bottles worth, I have seen no improvement in my evil 11s. I feel like I have lost valuable treatment time by giving this serum a good faith try and have cancelled auto-delivery. 12-15-13
Rated 5 out of 5 by Need time to see results Dr. P is way ahead of his time in skin care. I use this by adding a drop to the Acyl- Cream. You use very small amounts of his products but if used on regular consistent basis you will see differences in your skin. If you find the products a bit drying use a little of the Chia oil combined and that takes care of that concern. I totally use Perricone and have mostly switched to his Neuropeptides at this point but this is one product that I work into the mix daily on my skin. His products are high end price points but you really do use drops on your whole face so they do last for quite some time. For me it is worth cutting back in other areas to use his skin care. I do and have recommended many of his products to my friends and family. 11-02-13
Rated 5 out of 5 by I have had great results with this product WHAT!? This product has worked better than anything I have tried for deep wrinkles! This product deserves way better than 2 stars. My 11's are gone. Deep line from corner of mouth to end of chin no longer deep. Please try. I have started on second bottle. Small bottle but lasts a long time. Work into wrinkle &spread out like Dana always shows . Getting ready to start my granddaughter on it. Hope goes back on easy pay. Gave her a sample of mine & she is noticing results right away. She was complaining of the 11's lines . She is 27 and I told her you need to address wrinkles BEFORE they get out of hand. I started using this product July 2012 . I had just had back surgery. I kept it by my chair & 3 times a day , I messaged it into my wrinkles. I still am doing this today. Remember it only takes a small amount, but you will see big results. 10-28-13
Rated 2 out of 5 by Not what was expected I bought this product when it was combined with the face cream. I used both as instructed and noticed no improvement in deep facial lines. It feels good on the skin but for 150 dollars it is cheaper to get Botox which works lol dr denese peptide products did work on forehead lines sorry go back to the drawing board! 10-09-13
  • 2016-09-23 T10:57:51.562-05:00
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