Perricone MD Acyl- Glutathione & Cold Plasma Sub-D Duo

Perricone MD Acyl- Glutathione & Cold Plasma Sub-D Duo
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Reveal a More Youthful Look

"Dr. Perricone cracked the code for what causes us to experience advanced signs of aging. Using Acyl-Glutathione in a topical form can target creases on the skin. This is a must for use every morning and night.

With Cold Plasma Sub-D, Dr. Perricone has created a powerful at-home treatment. The ingredients, along with his Plasma Delivery System, help improve your neck area for a younger, firmer, smoother neck and chin."

—Dana Bledsoe

What is it: A two-step treatment system that helps address the appearance of the signs of aging from the face to the decollete.

Who is it for: Anyone who desires younger-looking skin.

Why is it different: For over 25 years, Dr. Perricone has been studying the signs that contribute to visible aging of the skin. He developed a technology that can help address this.

In a consumer use study of Acyl-Glutathione, 85% of subjects reported an improvement in the appearance of horizontal forehead lines after four weeks; 90% reported an improvement in the appearance of the "11 lines" between the eyes; 85% reported an improvement in the appearance of nasal-labial creases on the sides of the nose down to the mouth; and 88% reported an improvement in marionette creases from the sides of the mouth down to the chin. Also, 90% reported an improvement in the look of skin elasticity, resiliency, and firmness; 77% were amazed at how it improved the appearance of firmness of skin; and 85% reported an improvement in the level of moisture, hydration, and appearance of skin's pore size.

Cold Plasma Sub-D is formulated with a unique delivery system that addresses the appearance of the signs of aging on the neck and chin. Based on the results of an independent consumer use test, after 45 days of use, 69% agreed to somewhat agreed that by using this cream they look better and feel more confident.

How do I use it: Warm up a small amount of Acyl-Glutathione between your hands and spread over entire face. Slide your fingertips from the center of eyebrows toward the outside of the forehead. Then with your palms, go over temples, cheekbones, and sides of nose. Apply in the morning and evening on well-cleansed skin.

You don't need a lot of Cold Plasma Sub-D. Apply on chin, along the jawline, neck, and decollete areas both morning and evening. Massage up behind the ears and on the back of the neck.

From Perricone MD.


  • 1-oz Acyl-Glutathione
  • 2-oz Cold Plasma Sub-D

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Saturday, April 8, 2017 from Midnight – 1 a.m., 3 – 4 a.m., 6 – 7 a.m. ET

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Reviews & Community QA

Perricone MD Acyl- Glutathione & Cold Plasma Sub-D Duo is rated 4.0 out of 5 by 2.
Rated 3 out of 5 by from GOOD CREAMS BUT NEED MORE TIME I have used the Cold Plasma Sub-D religiously for approximately one year. It has helped my neck keep from deteriorating. However, I do not believe it has transformed it so much. I don't think my neck was in as bad a shape as I perceived so dramatic results were not necessary. However, I have not gotten any new wrinkles or loose looking skin in that area. My neck is sort of my pet worry right now being 47 and wishing I could stay looking 37. I have used the Acyl-Gluathione very sparingly as I have a very small container. I think I need to use more of it and more often to find any real big results. I do know that Acyl-Gluathione has great anti aging properties.
Date published: 2015-03-03
Rated 5 out of 5 by from Really Great! Love both of these products, really work. Love the new lemon smell!
Date published: 2015-03-01
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