Dr. Denese Wrinkle Rx 76% Peptide Solution Concentrate


What is it: A cutting-edge concentrate that helps fight the signs of aging.

Who is it for: Anyone who wants to renew their complexion.

Why is it different: This concentrate is composed of nine different peptide solutions. The concentration of pure peptides in the nine peptide solutions ranges from 1/100 of a percent to 1/2 of a percent. The breakthrough combination of neuropeptides and advanced technology helps to change the appearance of deep lines, transform skin's smoothness, and give you a more youthful-looking complexion.

How do I use it: Apply once or twice a day to clean skin. Use it as your first layer of skin care, depending on your need. Follow with night or day creams.

From Dr. Denese.

  • Net weight 1 fl oz

Tune in to QVC for Dr. Denese SkinScience

Thursday, June 9, 2016 from 1 – 2 a.m., 7 – 8 p.m. ET


Water, Cyclomethicone, Caprylic/Capric Triglyceride, Glycerin, Dipropylene Glycol, Sodium Hyaluronate, Dimethicon/Vinyl Dimethicone Crosspolymer, PEG/PPG-19/19 Dimethicone, Hydrolyzed Rice Protein, Butylene Glycol, Lecithin, Acetyl Glutamyl Heptapeptide-1, Malus Domestica Fruit Cell Culture, Rh-Polypeptide-7, Tripeptide-1, Caprooyl- Tetrapeptide-3, Avena Sativa (Oat) Kernel Protein, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-8, Palmitoyl Tripeptide-5, Oligopeptide-4, Diacetyl Boldine, Adenosine, Arginine, Dipotassium Glycyrrhizate, Tocopheryl Acetate, Guanidine, Glucose, Dextran, BIS-PEG-18 Methyl Ether Dimethyl Silane, Dimethiconol, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Phosphate, EDTA, Sodium Chloride, Sodium Polyacrylate

About Dr. Denese

Considered an industry leader in breakthrough scientific skin care technology, Adrienne Denese, M.D. Ph.D., trained at Harvard and Cornell University Medical College. She specializes in products that address the visible signs of aging. Dr. Denese's number-one priority is providing the most advanced scientific formulas, and she believes the key to high-performance skin care is using the right ingredients.

Eight years ago, Dr. Denese launched her skin-care line on QVC to much success. In 2005, QVC awarded the brand the Rising Star Award in recognition of its innovative skin care delivery systems and potent, novel, and effective ingredients that deliver what they promise. In 2009, HydroShield Ultra Moisturizing Face Serum won the QVC Customer Choice Beauty Award in the anti-aging category. Many products in the line are QVC customer top rated and best sellers. Not surprisingly, Dr. Denese has a large celebrity and socialite following who depend on her performance-oriented skin care.

Dr. Denese has been featured by many well known talk shows and magazines. Along with being a best-selling author, Dr. Denese has developed two highly regarded and widely viewed public television lecture series on anti-aging skin care.

Information provided by Dr. Adrienne Denese.

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Reviews & Community QA

Rated 4.1 out of 5 by 44 reviewers.
Rated 4 out of 5 by GREAT SERUM!!! BOTTLE HAS TO GO!!!!! I love the ingredients in this serum! It is truly a high end product. DR DENESE, PLEASE REFORM THE BOTTLE--IT IS SO USER UNFRIENDLY. We need to see when we are running out. You are all about providing the finest for us--please consider this! This is why only 4 stars--product should be 10 stars! 04-24-16
Rated 5 out of 5 by Expensive but the results are worth it! I use two pumps of this product twice daily, and the fine lines and wrinkles are seemingly disappearing from my face. In conjunction with the Firming Facial Pads, I don't ever want to be without this product. I am now wearing less makeup because my complexion is looking so great! Bless you, Dr. Denese! 03-18-16
Rated 5 out of 5 by Miracle! OMGosh! I have finally found something that does turn back the hands of time! I realize it is somewhat pricey but it is worth every penny to me. Everyone I see comments on my face, the smoothness on my forehead, upper lip and sides of my mouth! More Dr. Denese followers need to take the plunge and try this. It is a game changer! 12-22-15
Rated 5 out of 5 by WE HAVE A WINNER HERE!!! This is a WINNER!!! I am in my mid 40's and for me, this is the perfect product! It does exactly what it claims to do!! My skin looks beautiful and has not felt this soft or looked this good in over 20 years. I see results under my eyes, above my lips and my 11's are even looking better. I will repurchase!!! 11-19-15
Rated 5 out of 5 by WOW, WOW, and WOW! I am in my mid 50's and have been using this serum for about 4 years. My skin has drastically improved and I attribute it to Dr. Denese's fabulous products. Before I used this treatment serum, I had fairly noticeable nasal labial fold lines. They are almost completely gone now. The fine lines around my lips are almost non existent as well. I would also say that my eye area has also shown a great improvement and that is remarkable since my eyes are my main skin issue! I know this may seem pricey for many, but it is well worth the splurge if you want to see results. As with any topical treatments, they aren't designed to work overnight. Be patient and you will see results. Great job, Dr. Denese. Please continue to make fabulous products and I will continue to buy them! QVC, I can't implore you enough to give Dr. Denese more air time! Her products ROCK! 02-05-15
Rated 2 out of 5 by amount of product I started using this in place of Wrinkle Rest...which was discontinued. Why? I do not know that was great product. It worked well, lasted much longer than this and the price was 62.00 less. I will not buy this product again...I got it on easy pay and it was gone before last payment. It is not as good as Wrinkle Rest. I am not happy. 11-09-14
Rated 1 out of 5 by AWFUL Didn't like this product at all! Dried my skin out. Horrible. 08-03-12
Rated 4 out of 5 by THE PERFORMANCE OF PEPTIDES… …is the secret of Dr. Denese’s products that work so very well… and this treatment has nine in concentrated form. I am very pleased with the results after two weeks of use in the P.M. only. My skin shows the smoothness, and decrease in deep lines. By using it as the first item after cleansing and Dr. Denese’s firming pads, it prepares my derma for those latter steps. Being able to apply it over my eyes has satisfactory performance in firming my eye lids and skin under the eyes. The fact that it is CONCENTRATED allows for minimal amount for application and only one pump is enough for my entire face and the important jaw line and neck… for me that alone is wondrous for that product. I agree with some reviewers that: it would be helpful to have a strip up/down the container to see how much product remains; but I also understand that the product must be protected from light that may lessen its efficacy. As far as the product dollars, it is a little high and a candidate for easy pay or in a kit duo. 03-30-12
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